姓名：怀其勇
学位：南开大学理学硕士、博士
职务：副教授（硕士生导师）
邮箱：[email protected]
学术兼职：山东省禁化武履约工作专家
研究方向：
课题组开展天然化合物的分子修饰及其抗肿瘤活性的研究，主要是设计合成甘草次酸和姜黄素的新型衍生物，并通过MTT法考查其抗癌活性，目的是获得高效低毒的抗癌前药，进而深入研究药物的作用机理和作用靶点，对中药发展和新药开发具有重要作用。
现阶段科研项目：
1. 山东省自然科学基金面上项目《抗生物附着活性原花青素类天然产物的合成研究》。
2. 山东省重点研发计划项目《甘草次酸衍生物取代吉非替尼前药的研发》。
3. 高性能水基环保粘合剂的研发。
发表论文与专利：
1. Synthesis and Evaluation of a Ferrocene-Bonded Silica Phase for RP-HPLC，Q.Y.Huai, X.L.wang, Y.M.Zuo, Chromatographia, 2002, 55(9/10): 549-553.
2. Evaluation of the Retention Characteristics of Ferrocene-bonded Silica Reversed Phases for HPLC Using Linear Solvation Energy Relationships，Q.Y. Huai, J.M.You, Q. wang and Y. M. Zuo, Chromatographia, 2003, 57 (11/12): 709-713.
3.Preparation and Evaluation of an End-Capped p-tret-Butyl-Calix[4]arene-Bonded-Silica Stationary Phase for RP-HPLC，Q.Y. Huai, B. Zhao, Y.M. Zuo, Chromatographia, 2004, 59 (9/10): 637-645.
4. Study of the Retention Characteristics of Calix[4]arene-bonded Silica Stationary Phase and Comparison with Common Phases for HPLC Using Linear Solvation Energy Relationships，Q.Y. Huai, Y.M. Zuo, Journal of Liquid Chromatography & Related Technologies, 2006, 29:799-812.
5. 对-叔丁基-杯[4]芳烃键合硅胶固定相以及其它硅胶基质键合固定相的色谱保留性质，怀其勇,左育民,分析化学, 2006,34(7):919 - 922.
6. Synthesis of Porous Titaniaspheres for HPLC by Polymerization-Induced Colloid Aggregation (PICA) Using tert-n-Butyl Titanate，Q.Y. Huai, Y.M. Zuo, Journal of Analytical Chemistry，2009, 64(2):169-173.
7. Synthesis and antimicrobial activities on Staphylicoccus aureus of miscellaneous atomic curcumin derivatives，Huasen Wang,Qiyong Huai*,Asian Journal of Chemistry，Volume 25 (2013)，9:4836-4839.
8. Synthesis and electrochemical properties of ferrocene formylated curcumin，Xiushang Xu, Lingkai Kong,Qiyong Huai*,Asian Journal of Chemistry,Volume 25 (2013)，13:7637-7638.
9. Fast detection of saxitoxin using laser tweezers surfaceenhanced Raman spectroscopy，Qi-yong Huai, Chun-lei Gao,Jin-lai Miao, Hui-lu Yao and Zong-ling Wang，Analytical Methods，2013,5,6870–6873.
10. Synthesis and Properties of Copper(II)-Ferrocene Formylated Curcumin，Qiyong Huai, JunqiangYU,Xiushang Xu, Jinlai Miao, Zongling Wang,Asian Journal of Chemistry，Volume 26 (2014)，1:261-263.
11. Anti-Allergic and Antioxidant Effects of Flavonoid Glycosides Isolated from Hop (Humulus lupulus L) Flowers，Yang Li, Hua Yin, Zhonghua Qian, Jinlai Miao andQiyong Huai*，Asian Journal of Chemistry，Volume26(2014)，10:3061-3063.
12. Synthesis and Performance of Ferrocene-BondedChiral Stationary Phase forRP-HPLC，Huijing Li, Zhifang Song, Junqiang Yu, Yang Li, Ling Feng andQiyong Huai*，AsianJournal ofChemistry，Volume 26(2014)，14：4465-4468.
13. Synthesis and Biological Evaluation of Novel Curcuminoids Derivatives，Yakun Cao, huijing Li, zhifang Song, yang Li,Qiyong Huai *，Molecules，2014，19：16349-16372.
14. Synthesis and Evaluation of Antibacterial and Antitumor Activities of Apigenin Derivatives，Ling Feng, Ya-Kun Cao, Yang Li, Zhi-Fang Song andQi-Yong Huai*，Asian Journal of Chemistry，Volume27(2015)，8:2830-2832.
15. Rearrangement of Dypnones to 1,3,5-Triarylbenzenes,Kai Deng§,Qi-Yong Huai§, Zhi-Lun Shen,Hui-Jing Li,Chen Liu,and Yan-Chao Wu,Organic Letters,2015, 17:1473−1476.
16. Synthesis and Biological Evaluation of Curcuminoid Derivatives，Ling Feng,Yang Li,Zhi-fang Song,Hui-jing Li,andQi-yong Huai*,Chemicaland Pharmaceutical Bulletin,2015，63：873–881.
17. Synthesis and anticanceractivitiesofGlycyrrhetinicAcid Derivatives，Yang Li , Ling Feng , Zhi-Fang Song , Hai-Bei Li andQi-Yong Huai*，Molecules，2016，21(2), 199-218.
18. Design and Synthesis of New Anticancer Glycyrrhetinic Acids and Oleanolic Acids,Rui Wang, Qing-xuan Zheng,Wei Wang,Ling Feng,Hui-jing Li, andQi-yong Huai*,Biological and Pharmaceutical Bulletin,2017, 40(5):703-710.
19. Efficient Synthesis of Functionalized 4H-Chromenes via an Fe(OTf)3-Catalyzed Cyclization Reaction of Phenols and Ketones,Kai Deng,Qi-Yong Huai,Hui-Jing Li,Jun-Hu Wang,Hui-Ru Yang,Ying Liu,Yan-Chao Wu, Synthesis,2018,50, 1482–1492.
20. Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties, Rui Wang,Yang Li,Xu-Dong Huai,Qing-Xuan Zheng,Wei Wang,Hui-Jing Li,Qi-Yong Huai*,Drug Design, Development and Therapy,2018,12:1321–1336.
21. Design and synthesis of the novel oleanolic acid-cinnamic acid esterderivatives and glycyrrhetinic acid-cinnamic acid ester derivatives withcytotoxic properties,Rui Wang, Wei Yang, Yiqing Fan, Wim Dehaen, Yang Li, Huijing Li, Wei Wang,Qingxuan Zheng,Qi-Yong Huai*,Bioorganic Chemistry,2019 (88) 102951:1–15.
22. Design, Preparation and Studies Regarding Cytotoxic Properties ofGlycyrrhetinic Acid Derivatives,Qing-Xuan Zheng,Rui Wang,Yan Xu,Chang-Xin He,Cai -Yun Zhao,Zhi-Fang Wang,Rui Zhang,Wim Dehaen,Hui-Jing Li,andQi-Yong Huai*,Biological and Pharmaceutical Bulletin, 2020, 43(1): 102-109.
23. 一种制备无纺布专用乳胶漆的方法 怀其勇，马庆林,中华人民共和国发明专利，专利号ZL 201010280333.6
24. 一种活性姜黄素衍生物及其制备方法 怀其勇，马庆林,中华人民共和国发明专利，专利号ZL 201210525212.2
